|
KMID : 0620920090410080584
|
|
Experimental & Molecular Medicine
2009 Volume.41 No. 8 p.584 ~ p.591
|
|
|
Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes
|
|
Shim Jae-Woong
Jo Seong-Ho
Kim Sang-Doo
Lee Ha-Young
Yun Jean-Ho
Bae Yoe-Sik
|
|
|
Abstract
|
|
|
|
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1β production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1β production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
|
|
|
KEYWORD
|
|
|
cell migration inhibition, chemotaxis, leukocyte, interleukin-1β, lysophosphatidylglycerol, phagocytes, receptors, formyl peptide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|